The legal requirement for people who test positive for coronavirus to self-isolate will be removed from Thursday.
However, those who test positive for the virus will still be encouraged to follow the guidance to stay at home.
Vaccinated contacts of positive cases will no longer be asked to test for seven days and there will no longer be a legal requirement for close contacts who are not vaccinated to self-isolate.
Contact tracing will also come to an end.
A month later, on 24 March, the government will remove the COVID provisions attached to statutory sick pay.
Free symptomatic and asymptomatic testing will end in England from 1 April, the PM has announced.